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HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required)

From	National Institutes of Health
Who can apply	state governments, counties, cities and townships, special districts (water, fire, parks, etc.), school districts, public colleges and universities and 9 more types
Eligibility notes	Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.)
How much	Amount not stated
Deadline	Fri, Oct 30, 2026 (7 days left)
Category	Health
Type	Grant
Opportunity #	PAR-27-045
Assistance listing	93.121, 93.213, 93.273, 93.286, 93.473, 93.846, 93.853, 93.866
Posted	Mon, Sep 28, 2026

Open the official posting

From the notice

The NIH Helping to End Addiction Long-term® (HEAL) Initiative is releasing this Notice of Funding Opportunity (NOFO) to support a phased mechanistic clinical research program focusing on understudied biological mechanisms that drive joint pain. The phased projects supported by this program (of up to five years total in duration) will first identify and validate multi-tissue mechanisms underlying joint pain, then test non-pharmacologic or multimodal interventions that directly target these mechanisms. The initiative responds to priorities identified in the 2023 HEAL Whole Joint Pain Workshop and supports the broader goals of the NIH HEAL Initiative and the Make America Healthy Again vision by advancing safe, non-addictive, and prevention-oriented approaches to chronic pain.

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